AAI101, a Novel β-Lactamase Inhibitor: Microbiological and Enzymatic Profiling
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In Vitro Activity of Cefepime/AAI101 and Comparators against Cefepime Non-susceptible Enterobacteriaceae
We evaluated the in vitro potency of cefepime combined with AAI101, a novel extended-spectrum β-lactamase inhibitor, against a population of clinical Escherichia coli and Klebsiella pneumoniae collected from USA hospitals. Of the 223 cefepime non-susceptible isolates, 95% were ceftazidime non-susceptible, 49% ertapenem non-susceptible, 57% piperacillin/tazobactam non-susceptible, 90% were multi...
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The combination of cefepime with AAI101, a novel extended-spectrum β-lactamase inhibitor, possesses potent in vitro activity against many resistant Gram-negative pathogens. Against a panel of 20 mostly carbapenemase-producing cefepime-nonsusceptible strains of the family Enterobacteriaceae, we evaluated the MICs of cefepime in the presence of various fixed AAI101 concentrations (1, 2, 4, 8, and...
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1197. Frequency of Antimicrobial Resistance in Shiga Toxin-Producing Escherichia coli (STEC) and Non-Typhoidal Salmonella (NTS) Clinical Infections and Association with Epidemiological Factors Sanjana Mukherjee, MS; Rebekah Mosci, MS; Chase Anderson, -; Brian Snyder, BS; James Collins, MPH, RS; James Rudrik, PhD and Shannon D. Manning, PhD; Microbiology and Molecular Genetics, Michigan State Un...
متن کاملThe β-lactamase inhibitor avibactam (NXL104) does not induce ampC β-lactamase in Enterobacter cloacae
Induction of ampC β-lactamase expression can often compromise antibiotic treatment and is triggered by several β-lactams (such as cefoxitin and imipenem) and by the β-lactamase inhibitor clavulanic acid. The novel β-lactamase inhibitor avibactam (NXL104) is a potent inhibitor of both class A and class C enzymes. The potential of avibactam for induction of ampC expression in Enterobacter cloacae...
متن کاملتعیین الگوی مقاومت ایزولههای بالینی اشریشیاکلی مولد بتالاکتامازهای وسیعالطیف نوع AmpC براساس خصوصیات فنوتیپی و ژنوتیپی
Introduction : The widespread use of β -lactam antibiotic has lead to the development of resistance to this group of antibiotics in bacterial pathogens due to β -lactamase production. This study was undertaken to determine the AmpC β -lactamase production in pathogens isolated from hospitalized patients at selected university hospitals of Tehran. Materials & Methods: Non-repeat clinical iso...
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